Table 4.

Median [95% prediction interval] values for Scr concentration and creatinine clearance (CLcr) for various postnatal days for three different typical individuals of 24, 27, and 32 weeks of gestation, retrieved from simulations (n = 1000). Volume of distribution is based on median weight (Wt) and fixed to 0.7 L/kg

Postnatal age	24 weeks GA			27 weeks GA			32 weeks GA
	Wt (g)	Scr (mg/dl)	CrCL (ml/min)	Wt (g)	Scr (mg/dl)	CrCL (ml/min)	Wt (g)	Scr (mg/dl)	CrCL (ml/min)
Day 1	621	0.50 [0.31–0.81]	0.22 [0.14–0.37]	779	0.61 [0.38–0.98]	0.23 [0.14–0.39]	889	0.79 [0.50–1.29]	0.24 [0.14–0.41]
Day 3	631	0.90 [0.58–1.24]	0.26 [0.15–0.44]	778	0.87 [0.57–1.19]	0.27 [0.16–0.45]	887	0.86 [0.56–1.24]	0.31 [0.17–0.49]
Day 7	658	0.79 [0.49–1.41]	0.33 [0.18–0.52]	790	0.72 [0.45–1.30]	0.37 [0.19–0.57]	907	0.61 [0.39–1.17]	0.43 [0.23–0.65]
Day 14	724	0.57 [0.38–1.11]	0.44 [0.23–0.65]	854	0.51 [0.35–0.97]	0.48 [0.27–0.71]	1000	0.44 [0.31–0.73]	0.56 [0.35–0.78]
Day 21	795	0.49 [0.33–0.87]	0.51 [0.29–0.74]	935	0.44 [0.31–0.71]	0.56 [0.35–0.78]	1168	0.39 [0.29–0.55]	0.63 [0.44–0.84]
Day 28	882	0.43 [0.31–0.69]	0.56 [0.36–0.78]	1053	0.40 [0.29–0.59]	0.61 [0.42–0.83]	1322	0.36 [0.28–0.50]	0.67 [0.49–0.86]
Day 35	992	0.41 [0.30–0.61]	0.60 [0.41–0.82]	1205	0.38 [0.29–0.52]	0.64 [0.46–0.85]	1434	0.35 [0.28–0.47]	0.69 [0.52–0.87]
Day 42	1132	0.39 [0.29–0.55]	0.63 [0.45–0.84]	1387	0.36 [0.28–0.50]	0.67 [0.49–0.86]	1513	0.34 [0.28–0.45]	0.71 [0.55–0.88]