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. 2021 Jan 19;11:613278. doi: 10.3389/fimmu.2020.613278

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Copyright © 2021 Beckman, Abdullah, Chen, Kirchner, Rivera-Rodriguez, Kiser, Nguyen, Zhang, Nguyen, Hebbel, Belcher and Vercellotti

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Loss of endothelial, but not hematopoietic, TLR4 expression prevents microvascular stasis. (A) Schematic for bone marrow chimera crosses using SS-Tlr4^-/- donor marrow into AA-Tlr4^+/+ or AA-Tlr4^-/- recipients. (B) Hemin-stimulated microvascular stasis in chimeric AA-Tlr4^+/+ (black) and AA-Tlr4^-/- (red) recipients that received SS-Tlr4^-/- marrow. (C) schematic for bone marrow chimera crosses using SS-Tlr4^+/+ donor marrow into AA-Tlr4^+/+ or AA-Tlr4^-/- recipients. (D) Hemin-stimulated microvascular stasis in chimeric AA-Tlr4^+/+ (black) and AA-Tlr4^-/- (red) that received SS-Tlr4^+/+ marrow. All treatment groups with n = 4 mice/group. P < 0.05 for all time points analyzed by multiple t-tests via Holm-Sidak method.