Table 2. Hazard ratios (HRs) and 95% confidence intervals (CIs) of colon and rectum cancer accoding to green-tea consumption.*.
| Green-tea consumption (cups/day) | P for trend | ||||
| <1 | 1 or 2 | 3 or 4 | 5+ | ||
| Colon | |||||
| No.of cases / person-year of follow-up | |||||
| Cohort 1 | 26/36,642 | 30/34,157 | 36/43,780 | 66/85,460 | |
| Cohort 2 | 39/84,398 | 29/68,774 | 36/62,753 | 43/74,911 | |
| Sex- and age-adjusted HR | |||||
| Cohort 1 | 1.0 | 1.25 (0.74-2.11) | 1.13 (0.68-1.86) | 1.02 (0.65-1.61) | 0.79 |
| Cohort 2 | 1.0 | 0.93 (0.58-1.51) | 1.11 (0.71-1.75) | 0.94 (0.61-1.45) | 0.93 |
| Pooled | 1.0 | 1.06 (0.75-1.52) | 1.12 (0.80-1.56) | 0.98 (0.71-1.34) | 0.80 |
| Multivariate HR1 | |||||
| Cohort 1 | 1.0 | 1.19 (0.70-2.03) | 1.08 (0.65-1.80) | 1.03 (0.65-1.64) | 0.87 |
| Cohort 2 | 1.0 | 0.96 (0.59-1.57) | 1.12 (0.70-1.77) | 0.93 (0.59-1.46) | 0.85 |
| Pooled | 1.0 | 1.06 (0.74-1.52) | 1.10 (0.78-1.55) | 0.97 (0.70-1.35) | 0.81 |
| Multivariate HR2 | |||||
| Cohort 1 | 1.0 | 1.16 (0.65-2.08) | 0.88 (0.49-1.58) | 0.82 (0.49-1.39) | 0.27 |
| Cohort 2 | 1.0 | 1.01 (0.57-1.78) | 1.23 (0.72-2.11) | 0.84 (0.48-1.45) | 0.67 |
| Pooled | 1.0 | 1.08 (0.72-1.62) | 1.05 (0.71-1.57) | 0.83 (0.57-1.21) | 0.27 |
| Rectum | |||||
| No.of cases / person-year of follow-up | |||||
| Cohort 1 | 18/36,642 | 20/34,157 | 22/43,780 | 51/85,460 | |
| Cohort 2 | 38/84,398 | 20/68,774 | 15/62,753 | 27/74,911 | |
| Sex- and age-adjusted HR | |||||
| Cohort 1 | 1.0 | 1.20 (0.63-2.27) | 1.01 (0.54-1.88) | 1.17 (0.68-2.00) | 0.68 |
| Cohort 2 | 1.0 | 0.65 (0.38-1.12) | 0.48 (0.27-0.88) | 0.64 (0.39-1.05) | 0.05 |
| Pooled | 1.0 | 0.84 (0.56-1.29) | 0.69 (0.45-1.06) | 0.84 (0.58-1.21) | 0.27 |
| Multivariate HR1 | |||||
| Cohort 1 | 1.0 | 1.34 (0.70-2.56) | 1.14 (0.60-2.15) | 1.34 (0.77-2.33) | 0.40 |
| Cohort 2 | 1.0 | 0.62 (0.36-1.06) | 0.44 (0.24-0.82) | 0.57 (0.34-0.95) | 0.02 |
| Pooled | 1.0 | 0.85 (0.56-1.29) | 0.70 (0.45-1.08) | 0.85 (0.58-1.23) | 0.31 |
| Multivariate HR2 | |||||
| Cohort 1 | 1.0 | 1.09 (0.49-2.41) | 1.00 (0.46-2.15) | 1.31 (0.68-2.51) | 0.39 |
| Cohort 2 | 1.0 | 0.54 (0.27-1.07) | 0.39 (0.18-0.84) | 0.66 (0.37-1.20) | 0.14 |
| Pooled | 1.0 | 0.73 (0.43-1.22) | 0.62 (0.36-1.07) | 0.90 (0.58-1.40) | 0.67 |
*: The multivariate hazard ratio (HR) has been adjusted for sex; age; family history of colorectal cancer; cigarette smoking; alcohol consumption; body mass index in kg / m2 (<18.5, 18.5-24.9, 25.0+ ); consumption of black tea, and coffee. The multivariate HR for cohortl has also been adjusted for consumption of meat, green-yellow vegetables, other vegetables, and fruits. The multivariate HR for Cohort2 has also been adjusted for consumption of beef, pork, ham, chicken, liver, spinach, carrot or pumpkin, tomato, orange, other fruits, and juice. HR1 denotes the relative risk with all cases of colorectal cancer included in the multivariate analysis, and HR2 the relative risk with cases diagnosed in the first three years of follow-up excluded from the analysis.
95% confidence intervals in parentheses.