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. 2021 Jan 19;10:607349. doi: 10.3389/fonc.2020.607349

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Copyright © 2021 Kulasinghe, Taheri, O’Byrne, Hughes, Kenny and Punyadeera

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of the Digital Spatial Profiling (DSP) platform (Nanostring Technologies, Seattle). Antibodies are covalently bonded to a DNA indexing oligo with a UV photo-cleavable linker. These reagents are used to stain HNSCC tumor tissue sections and focused UV light can liberate the indexing oligos from the regions of interest (ROI). The oligos can be collected and digitally counted. Image obtained with permission from Merritt et al., bioRxiv 2019.