TABLE 1.
Growth rate of M. tuberculosis in nontreated HFS-TB and kill rate with experimental and standard regimen.
TZD-MOXI | TZD-MOXI-FPM | Standard therapy | Nontreated control | |
---|---|---|---|---|
LPG | −0.28 ± 0.12 | Not tested | Not tested | 0.04 ± 0.011 |
SRB | −0.17 ± 0.027 | Not tested | Not tested | 0.035 ± 0.01 |
NRP | Not tested | −0.53 ± 0.09 | −0.59 ± 0.08 | −0.039 ± 0.01 |
TZD, tedizolid; MOXI, moxifloxacin; FPM, faropenem; LPG, log-phase growth; SRB, slowly replicating bacilli at acidic pH of 5.8; NRP, nonreplicating persisters. The growth and kill rates are given as log10 CFU/mL/day.