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. 2021 Jan 19;11:598847. doi: 10.3389/fimmu.2020.598847

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Copyright © 2021 Henning, Endt, Steigerwald, Anderson and Volkmann

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Survival and Body Temperature Changes after VEEV TrD Aerosol Challenge of Immunized Mice. Mice were immunized (IM) twice (Day 0 and 28) with the respective vaccine or TBS and then exposed to an aerosolized dose of VEEV TrD on Day 42. Kaplan-Meier plots of survival results (A) and changes in body temperature during the post-challenge period (B). There was a significant difference in survival between the TBS group and all three vaccination groups (p < 0.01). In addition, there was a significant (p < 0.05) temperature decrease for the TBS control group (B) prior to succumbing to infection or meeting euthanasia criteria and a significant difference between the TBS control group and the vaccinated groups on Days 44–49 (p < 0.05). Ten animals per group were evaluated for survival and body temperature changes.