Figure 3.

Immune Response After Immunization with Monovalent, Triple Mix, or Trivalent Vaccines. Mice were immunized (IM) twice (Day 0 and 28) with the respective vaccine or TBS. VEEV PRNT₅₀ (A), WEEV PRNT₅₀ (B), and EEEV PRNT₅₀ (C). On Day 28, the geometric mean MVA-WEEV PRNT₅₀ was significantly greater than the Trivalent and TBS control groups and on Day 42, the MVA-WEEV geometric mean PRNT₅₀ was significantly greater than the TBS group (p < 0.01). On Day 14, the geometric mean MVA-EEEV PRNT₅₀ was significantly greater than the Trivalent group and TBS control (p < 0.0001). On Day 42, the MVA-EEEV geometric mean PRNT₅₀ was significantly greater than the TBS control (p < 0.01). Five animals per group were evaluated at each time point for immune responses.