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L-arginine supplementation does not mediate inflammatory cytokine production. Renal mRNA expression of pro-inflammatory cytokines tnf-α, il-1β, and il-6 were measured in whole kidney lysate of male (A–C) and female (D–F) mice. rps12 served as the reference. The values shown are mean ± SEM. n indicates the number of animals used in the experimental groups. Data is expressed as the fold change to the young control group. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001.
