Figure 1.

Trial profiles and final dataset

MMC=mytomicin C. FU=fluorouracil. *98 excluded from chemotherapy randomisation (radiotherapy plus chemotherapy vs radiotherapy alone): 53 ineligible for chemotherapy; 34 withdrew or were withdrawn by physician; four had other reasons; and seven had unknown reasons. †239 excluded from radiotherapy randomisation (standard radiotherapy vs reduced high-dose volume radiotherapy): 84 entered the trial after radiotherapy randomisation closed; 54 at centres not participating in radiotherapy randomisation; 47 with multiple tumours; 44 withdrew or were withdrawn by physician; and ten with administrative or unknown reasons.