Figure 3.

Forest plots of the fractionation effect of 64 Gy in 32 fractions versus 55 Gy in 20 fractions for invasive locoregional control and overall survival (A) and toxicity (B)

Invasive locoregional control combined HR estimates adjusted for age, sex, randomised treatment, extent of resection, tumour stage, haemoglobin, and neoadjuvant chemotherapy. Overall survival combined HR estimates adjusted for age, sex, randomised treatment, extent of resection, tumour stage, and haemoglobin. Invasive locoregional control and overall survival were modelled on random effects for treatment site and stratified by trial. Late rectum or bladder toxicity combined absolute RD estimates adjusted for age, sex, randomised treatment, and trial, with a random-effects model for treatment site. Models were adjusted on the subset of patients with available values for variables in the model. Red dotted line represents the non-inferiority margin. HR=hazard ratio. RD=risk difference.