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. 2020 Oct 26;124(3):595–603. doi: 10.1038/s41416-020-01138-3

Fig. 5. IFN-γ is associated with Tmab-induced PD-L1 upregulation in HER2-amplified GC cells co-cultured with NK cells.

Fig. 5

a IFN-γ concentrations in conditioned media from co-culture experiments of HER2-amplified GC cells (NCI-N87 and NUGC4) with PBMC and NK cells by ELISA. b PD-L1 expression on HER2-amplified GC cells (NCI-N87 and NUGC4) that were monocultured or co-cultured with NK cells, and treated with Tmab or hIgG (5 μg/ml) plus a neutralising IFN-γ antibody (10 μg/ml) for 48 h by multicolour flow cytometry. The data are represented by histograms and MFI values. NS, no significant difference. *P < 0.05.