Table 1.
Region of interest-based volumes (expressed in cm3) and results of ANOVA for intergroup comparisons after normalization against total intracranial volume.
| Healthy controls (N = 32) | Patients with early-stage PD (N = 39) | Patients with late-stage PD (N = 37) | p | |
|---|---|---|---|---|
| TIV | 1193.91 ± 98.50 | 1184.51 ± 154.55 | 1155.85 ± 160.15 | |
| SN (right) | 0.144 ± 0.018 | 0.138 ± 0.02 | 0.130 ± 0.013 | 0.12 |
| SN (left) | 0.142 ± 0.022 | 0.128 ± 0.016 | 0.125 ± 0.020 | 0.08 |
| Putamen (right) | 4.51 ± 0.62 | 4.50 ± 0.62 | 4.12 ± 0.96 | 0.11 |
| Putamen (left) | 4.57 ± 0.74 | 4.55 ± 0.58 | 4.18 ± 0.85 | 0.10 |
| Thalamus (right) | 7.35 ± 0.92 | 7.48 ± 0.86 | 7.65 ± 0.99 | 0.18 |
| Thalamus (left) | 7.26 ± 0.84 | 7.28 ± 1.08 | 7.26 ± 1.15 | 0.13 |
| Caudate (right) | 3.90 ± 0.50 | 3.86 ± 0.60 | 3.82 ± 0.74 | 0.12 |
| Caudate (left) | 3.85 ± 0.46 | 3.65 ± 0.53 | 3.60 ± 0.58 | 0.08 |
| STN (right) | 0.112 ± 0.018 | 0.108 ± 0.019 | 0.104 ± 0.019 | 0.09 |
| STN (left) | 0.106 ± 0.02 | 0.103 ± 0.017 | 0.101 ± 0.01 | 0.10 |
PD Parkinson’s disease, TIV total intracranial volume, SN substantia nigra, STN sub-thalamic nucleus.