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. 2021 Feb 1;11:88. doi: 10.1038/s41398-020-01147-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Venn diagram of overlapping VMPs for GRADY, PReDICT, and U19 at a MAD score threshold at the 80th percentile (a). Distribution of the best models explaining variation in DNAm across the three adult cohorts. Percentage of overlapping VMPs (n = 45,962) best explained by G, CA, G + CA, or G × CA in each cohort using the highest adjusted R² (b). Consistent best models across three adult cohorts. Percentage of overlapping VMPs (n = 45,962) best explained by the same model type (G, CA, G + CA, or G × CA) in at least two cohorts (c).