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. 2021 Feb 1;11:88. doi: 10.1038/s41398-020-01147-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Histone mark enrichment for overlapping VMPs with regard to other 450K CpG sites (above panel) (a). Histone mark enrichment for overlapping VMPs (below) with at least two consistent best G, G + CA, or G × CA models against overlapping VMPs with no consistent models. Green color indicates depletion, and red color indicates enrichment. Thick black lines around the rectangles indicate significant enrichment/depletion based on Fisher’s tests and a Bonferroni threshold of p < 4.66 × 10⁻⁰⁴. VMPs with at least two consistent best G × CA models were enriched in repressed Polycomb (p = 5.48 × 10⁻¹⁹, OR = 1.19, Fisher’s test) (b). Average distance between SNP and CpG site for consistent best G (left), consistent best G + CA (middle), and consistent G × CA models (right). CpGs with at least two consistent G × CA models presented with a significantly longer distance between SNP and VMP than VMPs with other consistent models (mean absolute distance = 271.83 kb, p < 2.20 × 10⁻¹⁶, Wilcoxon’s test) (c).