Table 1.
Demographic overview of cohorts.
| Cohort | Na | Mean age (SD) | Sex (male) | Ethnicity | Assessment of CA | CA Na (%) | Tissue | Methylation array |
|---|---|---|---|---|---|---|---|---|
| GRADY | 309 | 42.08 (12.92) | 25.56% | African American | Self-report | 148 (47.90%) | Whole blood | 450K |
| PReDICT | 363 | 39.83 (11.50) | 39.67% | Mixed | Self-report | 164 (45.18%) | Whole blood | 450K |
| U19 | 78 | 39.27 (12.10) | 0.00% | Mixed | Self-report | 66 (84.62%) | Whole blood | 450K |
| BerlinLCS | 173 | 4.23 (0.79) | 52.60% | Caucasian | Documented | 86 (49.71%) | Saliva | EPIC |
| HBCS | 151 | 63.5 (2.8) | 100% | Finnish | Documented | 77 (51.00%) | Whole blood | 450K |
In GRADY, PReDICT, and U19 CA refers to moderate-to-severe ranges of CTQ scores for either sexual, physical, or emotional abuse (GRADY n = 77, PReDICT n = 79, U19 n = 14) or to moderate-to-severe scores in at least two abuse groups (GRADY n = 71, PReDICT n = 85, U19 n = 52), in BerlinLCS CA refers to maltreatment and in HBCS to evacuation and separation from parents in World War II.
SD standard deviation, CA childhood adversity.
aN = sample size.