Table 2.
Pharmacologic management of orthostatic hypotension
| Drug | Mechanism | Dosage |
|---|---|---|
| Primary choices | ||
| Midodrine | α1-Adrenoreceptor agonist | 7.5–30 mg daily |
| Droxidopa | Norepinephrine prodrug | 300–1800 mg daily |
| Secondary choices | ||
| Fludrocortisone | Mineralocorticoid | 0.1–0.4 mg daily |
| Pyridostigmine | Acetylcholinesterase inhibitor | 60–180 mg daily |
| Consider in refractory situations (inadequately tested) | ||
| Desmopressin | Vasopressin receptor agonist | 2–4 μg daily (i.m.) |
| Octreotide | Somatostatin receptor agonist | 12.5–25 μg daily |
| Methylphenidate | Norepinephrine/dopamine reuptake inhibitor | 15–30 mg daily |
| Yohimbine | α2-Adrenoreceptor antagonist | 5.4 mg daily |
| Indomethacin | Prostaglandin synthesis inhibitor | 50 mg daily |