Table 4.

Summary of risk of bias assessment for non-randomized studies-ROBINS-1 tool

Domain	Yamasaki et al. [27]	Spielmann et al. [25]	Patil et al. [40]	Ciur et al. [41]	Nemtoi et el [30].
Bias due to confounding	Serious	Serious	Moderate	Moderate	Moderate
Bias in selection of participants for the study	Serious	Moderate	Moderate	Moderate	Moderate
Bias in classification of interventions	Moderate	Low	Low	Low	Low
Bias in measurement of outcomes	Serious	Serious	Moderate	Moderate	Moderate
Bias in selection of the reported result	Moderate	Low	Low	Low	Low
Overall	Serious	Serious	Moderate	Moderate	Moderate