Table 7.
Quality of available evidence on the rate of orthodontic tooth movement for the RCT
| Quality assessment | Effect | Quality | |||||
|---|---|---|---|---|---|---|---|
| Studies | Risk of bias | Inconsistency | Indirectness | Imprecision | Other | ||
| Vit D | |||||||
| 2 | Seriousa | Not serious | Not serious | Not seriousa | None |
Al-Hasani [26]: no effect Varughese [43]: increased in the EG |
⨁⨁⨁◯b Moderate |
| HRH | |||||||
| 1 | Not Serious | Not serious | Not serious | Not serious | None | No difference |
⨁⨁⨁⨁ High |
| PRP | |||||||
| 1 | Not serious | Not serious | Not serious | Not serious | None |
Tehranchi [31]: no effect El-Timamy [32]: no effect |
⨁⨁⨁⨁ High |
| Vit C | |||||||
| 1 | Seriousa | Not serious | Not serious | not serious | None | Increased in the EG |
⨁⨁⨁◯b Moderate |
EG experimental group, HRH human relaxin hormone, PRP platelet-rich plasma, Vit C vitamin C, Vit D vitamin D
aThe results overall are based only on few studies
bOwing to the lack of concealed allocation in the randomization, the respective grading of evidence started as moderate