Experimental design and animal groups. ICH, intracerebral hemorrhage; CCL17, C-C chemokine ligand17; rCCL17, recombination C-C chemokine ligand17; CCR4, C-C chemokine receptor 4; Nrf2, nuclear factor erythroid 2-related factor 2; WB, western blot; IF, immunofluorescence; HV, hematoma volume; HC, hemoglobin content; BWC, brain water content; CRISPR, clustered regularly interspaced short palindromic repeats; DMSO, dimethyl sulfoxide; i.n., intranasally; i.c.v., intracerebroventricularly