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PAC1/AC/cAMP/PKA pathway involved PACAP-mediated neuroprotection after SAH. (a) Representative western blot bands. (b) Densitometric quantification of PACAP, PAC1, cAMP, PKA, p-PKA, AQP4, MMP-9, and ZO-1. (c) Representative western blot bands of co-IPs. (d) Densitometric quantification of SUR1 input, SUR1 immunoprecipitated with phospho antibody, and SUR1 immunoprecipitated with AQP4. n = 4–6/group. *P < 0.05, **P < 0.01. One-way ANOVA, Tukey’s post hoc test
