Fig. 4.

mPDM608 treatment decreases the neuroinflammatory response observed following MPTP intoxication. (a) Immunohistochemistry of Mac-1⁺ microglia in the substantia nigra of mice treated with either PBS, MPTP, 1.0 mg/kg mPDM608, 3.0 mg/kg mPDM608, 5.0 mg/kg mPDM608, 10.0 mg/kg mPDM608, or 0.1 mg/kg rGM-CSF followed by MPTP intoxiction (× 40 image; scale bar, 1000 μm; inset image = × 200). (b) Quantification of reactive microglia within the substantia nigra 2 days post MPTP intoxication. Differences in means (± SEM, n = 5) were determined in which p < 0.05 compared with ^aPBS or ^bMPTP treatment