Fig. 6.

mPDM608 treatment attenuates striatal termini loss. (a) Representative immunohistochemical sections of TH+ dopaminergic cell termini within the striatum of mice treated with either PBS, MPTP alone, or MPTP and mPDM608 at doses of 0.1, 0.3, 1.0, 3.0, 5.0, 10.0, 15.0, 20.0, 25.0, or 30.0 mg/kg; MPTP and a single injection of 0.1 mg/kg rGM-CSF (1×); or 5 injections (5×) of 0.1 mg/kg rGM-CSF (scale bar = 500 μm). (b) Densitometry analysis of TH⁺ termini within the striatum following MPTP intoxication. Treatment groups are normalized to PBS control density. Differences in means (± SEM, n = 7) were determined in which p < 0.05 compared with groups treated with ^aPBS or ^bMPTP