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Allopregnanolone restored neuronal differentiation of adult 3xTgAD NSCs. (A) Allo treatment increased MAP2+ (green) neurons while decreasing GFAP+ (red) astrocytes derived from 3-month-old 3xTgAD NSCs. (B) The neuron/astrocyte ratio was increased from 100% (46.9% < μ < 153.1%) of vehicle group to 215% (119.7% < μ < 310.2%) of Allo group (p = 0.019, n = 5). The scatterplot represents mean values ± 95% CI.
