Table 2.
Summary of some tumor-related circRNAs.
| Cancer | CircRNA ID | expression | Function | Mechanism | Refs. |
|---|---|---|---|---|---|
| Glioma | circFBXW7 | Down-regulated | tumor suppressor | encoded peptides | [63] |
| circSHPRH | Down-regulated | tumor suppressor | encoded peptides | [69] | |
| circSMARCA5 | Down-regulated | tumor suppressor | circSMARCA5/SRSF1/SRSF3 | [106] | |
| circITCH | Down-regulated | tumor suppressor | circITCH/miR-214 | [107] | |
| circNFIX | Up-regulated | oncogene | circNFIX/miR-34a-5p | [108] | |
| circNT5E | Up-regulated | oncogene | circNT5E/miR-422a | [109] | |
| circTTBK2 | Up-regulated | oncogene | miR-217/HNF1β/Derlin-1 | [110] | |
| hsa_circ_0000177 | Up-regulated | oncogene | hsa_circ_0000177/miR-638-FZD7/Wnt | [111] | |
| hsa_circ_0012129 | Up-regulated | oncogene | hsa_circ_0012129/miR-661 | [112] | |
| circCFH | Up-regulated | oncogene | circ-CFH/miR-149/AKT1 | [113] | |
| hsa_circ_0046701 | Up-regulated | oncogene | hsa_circ_0046701/miR-142-3p/ITGB8 | [114] | |
| HCC | circMTO1 | Down-regulated | oncogene | circMTO1/miR-9 | [117] |
| circSMARCA5 | Down-regulated | tumor suppressor | circSMARCA5/miR-17-3p | [118] | |
| circZKSCAN1 | Down-regulated | tumor suppressor | PI3K pathway | [119] | |
| hsa_circ_0003570 | Down-regulated | oncogene | Unknown | [120] | |
| Cdr1as | Up-regulated | oncogene | Cdr1as /miR-7 | [121] | |
| Colorectal | hsa_circ_0000069 | Up-regulated | oncogene | Unknown | [124] |
| cancer | hsa_circ_0007534 | Up-regulated | oncogene | Unknown | [125] |
| hsa_circ_103809 | Down-regulated | oncogene | Unknown | [126] | |
| hsa_circ_104700 | Down-regulated | oncogene | Unknown | [126] | |
| CircCCDC66 | Up-regulated | oncogene | CircCCDC66/miR-93 | [127] | |
| Circular BANP | Up-regulated | oncogene | Circular BANP/p-Akt | [128] | |
| hsa_circ_001569 | Up-regulated | oncogene | hsa_circ_001569/FMNL2 | [129] | |
| Cdr1as | Up-regulated | oncogene | ciRS-7/miR-7 /EGFR | [130] | |
| Gastric | hsa_circ_0000190 | Down-regulated | oncogene | Unknown | [133] |
| hsa_circ_002059 | Down-regulated | oncogene | Unknown | [134] | |
| cancer | hsa_circ_0000199 | Up-regulated | oncogene | hsa_circ_0000199/miR-198 | [135] |
| circDLST | Up-regulated | oncogene | circDLST/miR-502-5p | [136] | |
| circPSMC3 | Up-regulated | oncogene | circPSMC3/miR-296-5p | [137] | |
| hsa_circ_0092303 | Up-regulated | oncogene | hsa_circ_0092303/miR-331-3p | [138] | |
| circNRIP1 | Up-regulated | oncogene | circNRIP1/miR-149-5p | [139] | |
| circLMTK2 | Up-regulated | oncogene | circLMTK2/miR-150-5p | [140] | |
| circSERPINE2 | Up-regulated | oncogene | circSERPINE2/miR-375 | [26] | |
| circDONSON | Up-regulated | oncogene | circDONSON/NURF complex | [141] | |
| hsa_circ_0008549 | Up-regulated | oncogene | hsa_circ_0008549/miR-136-5p | [142] | |
| Lung | hsa_circ_0008305 | Down-regulated | oncogene | hsa_circ_0008305/miR-429 | [144] |
| F-circEA-2a | Up-regulated | oncogene | Unknown | [145] | |
| cancer | hsa_circ_0011385 | Up-regulated | oncogene | hsa_circ_0011385/miR-361-3p | [146] |
| CircTP63 | Up-regulated | oncogene | CircTP63/miR-873-3p | [147] | |
| circENO1 | Up-regulated | oncogene | circENO1/miR-22-3p | [148] | |
| circFGFR1 | Up-regulated | oncogene | circFGFR1/miR-381-3p | [149] | |
| circSMARCA5 | Down-regulated | tumor suppressor | circSMARCA5/miR-19b-3p/HOXA9 | [150] | |
| AML | circDLEU2 | Up-regulate | oncogene | circDLEU2/miR-496/PPKACB | [151] |
| circHIPK2 | Up-regulated | oncogene | circHIPK2/miR-124-3p | [152] | |
| circPAN3 | Up-regulated | oncogene | circPAN3/miR-153-5p | [153] | |
| CLL | circCBFB | Up-regulated | oncogene | circCBFB/miR-607/FZD3/Wnt | [154] |
| hsa_circ_0132266 | Down-regulated | tumor suppressor | hsa_circ_0132266/miR-337-3p/PML | [155] | |
| circ-RPL15 | Up-regulated | oncogene | miR-146b-3p/RAF1 axis. | [156] | |
| CML | circBA9.3 | Up-regulated | oncogene | circBA9.3/c-ABL1 | [157] |
| hsa_circ_0080145 | Up-regulated | oncogene | hsa_circ_0080145/miR-29b | [158] | |
| circHIPK3 | Up-regulated | oncogene | circHIPK3/miR-124 axis | [159] | |
| MM | hsa_circ_0007841 | Up-regulated | oncogene | hsa_circ_0007841/miRNAs | [160] |
| hsa_circ_0000190 | Down-regulated | tumor suppressor | hsa_circ_0000190/miR-767-5p | [161] | |
| circITCH | Down-regulated | tumor suppressor | circITCH/miR-615-3p | [162] | |
| BC | circTCF25 | Up-regulated | oncogene | circTCF25/miR-103a-3p | [164] |
| hsa_circ_0001361 | Up-regulated | oncogene | hsa_circ_0001361/miR-491-5p | [165] | |
| circSLC8A1 | Down-regulated | tumor suppressor | miR-130b/miR-494 | [166] | |
| kidney | circHIAT1 | Down-regulated | tumor suppressor | circHIAT1/miR-195-5p/29a-3p | [167] |
| Cancer | hsa_circ_001895 | Up-regulated | oncogene | hsa_circ_001895/miRNA-296-5p | [168] |
| circNRIP1 | Up-regulated | oncogene | circNRIP1/miR-505 | [169] |
(HCC: Hepatocellular carcinoma; AML:acute myloid leukemia; CLL: chronic lymphocytic leukemia; MM: multiple myeloma; BC: bladder cancer)