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. 2021 Jan 22;19:910–928. doi: 10.1016/j.csbj.2021.01.018

Table 3.

The potential role of circRNAs as biomarkers in various cancers.

Cancer Name of CircRNAs Changes of expression Diagnostic significance ROC curve Numbers of patients Refs
HCC CircSMARCA5 Down Correlated with tumor differentiation, TNM stage, cancer invasion and cancer diameter Plasma circRNA;
AUC value: 0.938, 0.853, 0.711		 133 [177]
Hsa_circ_0000798 Up Correlated with tumor size and cirrhosis Plasma circRNA;
AUC value: 0.703		 102 [174]
Hsa_circ_0068669 Down Associated with microvascular invasion and TMN stages Tissue circRNA;
AUC value: 0.64; Sensitivity: 0.59;
Specificity: 0.71		 100 [178]
Hsa_circ_0027089 Up – Plasma circRNA;
AUC value: 0.794; Sensitivity: 0.578;
Specificity: 0.848		 239 [175]
Hsa_circ_0058124 Up Associated with tumor siz, tumor, node, TNM stage, and vascular invasion Tissue circRNA;
AUC value: 0.878		 128 [176]
Hsa_circ_0028502 Down Related to TNM stage Tissue circRNA;
AUC value: 0.675; Sensitivity: 0.721;
Specificity: 0.580		 200 [179]
Hsa_circ_0076251 Down Related to Barcelona Clinic Liver Cancer (BCLC) stage and the presence of serum HbsAg Tissue circRNA;
AUC value: 0.738; Sensitivity: 0.713;
Specificity: 0.640		 200
Colorectal
cancer		 Hsa_circ_0000567 Down Correlated with tumor size, lymph metastasis, distal metastasis, and TNM stage Tissue circRNA;
AUC value: 0.8653; Sensitivity: 0.8333;
Specificity: 0.7647		 204 [182]
Hsa_circ_0082182 Up Connected with lymph node
metastasis		 Plasma circRNA;
AUC value: 0.7371		 156 [180]
Hsa_circ_0000370 Up Connected with lymph node
metastasis		 Plasma circRNA;
AUC value: 0.8152		 156
Hsa_circ_0035445 Up Connected with the TNM stage Plasma circRNA;
AUC value: 0.7028		 156
Hsa_circ_0004585 Up Correlated with patient’s tumor size Plasma circRNA;
AUC value: 0.731; Sensitivity: 0.851;
Specificity: 0.511		 284 [181]
Hsa_circ-0004771 Up Correlated with TNM stage and distant metastasis Exosome circRNA;
AUC value: 0.90		 135 [195]
Gastric
cancer		 Hsa_circ_0003159 Down Associated with gender, distal metastasis and TNM stage Tissue circRNA;
AUC value: 0.75; Sensitivity: 0.852;
Specificity: 0.565		 108 [183]
Hsa_circ_0000096 Down Associated with gender, invasion and TNM stage Tissue circRNA;
AUC value: 0.82		 101 [184]
Hsa_circ_002059 Down Correlated with distal metastasis, TNM stage, gender and age Plasma circRNA;
AUC value: 0.73; Sensitivity: 0.81;
Specificity: 0.62		 101 [185]
Hsa_circ_0000190 Down Tissue circRNA: Related to tumor diameter, lymphatic metastasis, distal metastasis and TNM stage Tissue circRNA;
AUC value: 0.75; Sensitivity: 0.721;
Specificity: 0.683;
Plasma circRNA;
AUC value: 0.6; Sensitivity: 0.414;
Specificity: 0.875		 208 [133]
Hsa_circ_0000181 Down Correlated with tumor diameter, lymphatic metastasis, distal metastasis Tissue circRNA;
AUC value: 0.756; Sensitivity: 0.852;
Specificity:0.539
Plasma circRNA;
AUC value: 0.582; Sensitivity: 0.206;
Specificity: 0.99		 115 [186]
Hsa_circ_0001895 Down Correlated with GC cell differentiation, Borrmann type, and CEA level Tissue circRNA;
AUC value: 0.792; Sensitivity: 0.678;
Specificity:0.857		 257 [188]
Hsa_circ_0000467 Up Correleated with TNM stage Tissue circRNA;
AUC value: 0.799; Sensitivity: 0.705;
Specificity:0.648		 102 [187]
CircPSMC3 Down Associated with TNM stage and lymphatic metastasis Tissue circRNA;
AUC value: 0.933; Sensitivity: 0.536;
Specificity:0.857		 106 [137]
Hsa_circ_0000520 Down Tissue:associated with TNM stage
Plasma: linked with CEA expression.		 Tissue circRNA;
AUC value: 0.613; Sensitivity: 0.852;
Specificity:0.539
Plasma circRNA;
AUC value: 0.897; Sensitivity: 0.824;
Specificity: 0.844		 112 [192]
Oral squamous cell carcinoma Hsa_circ_0003829 Down Correlated with lymph node metastasis status and TNM stage Tissue circRNA;
AUC value: 0.81; Sensitivity: 0.7;
Specificity:0.8		 120 [197]
Hsa_circ_0001874 Up Correlated with TNM stage and tumor grade Salivary circRNA;
AUC value: 0.863; Sensitivity: 0.744;
Specificity:0.902		 93 [196]
Hsa_circ_0001971 Up Correlated with TNM stage Salivary circRNA;
AUC value: 0.845; Sensitivity: 0.756;
Specificity:0.878		 93 [196]
Lung
cancer		 Hsa_circ_0001715 Up Correlated with TNM stage and distant metastasis Plasma circRNA;
AUC value: 0.871; Sensitivity: 0.8772;
Specificity: 0.7167		 117 [198]
Hsa_circ_0005962 Up Related to EGFR mutations and gender Tissue circRNA;
AUC value: 0.73; Sensitivity: 0.719;
Specificity:0.722		 153 [199]
Hsa_circ_0086414 Down Related to gender Tissue circRNA;
AUC value: 0.81; Sensitivity: 0.778;
Specificity:0.722		 153
Hsa_circ_002178 Up – Exosome circRNA;
AUC value: 0.9956		 210 [194]
Hsa_circ_0037515 Down – Tissue circRNA;
AUC value: 0.81; Sensitivity: 0.57;
Specificity:0.90		 122 [200]
Hsa_circ_0037516 Down – Tissue circRNA;
AUC value: 0.82; Sensitivity: 0.65;
Specificity:0.84		 122
Breast cancer Hsa_circ_0008673 Up Correlated with tumor size,distant metastasis, ER positive and PR positive Plasma circRNA;
AUC value: 0.833; Sensitivity: 0.550;
Specificity: 0.971		 378 [189]
Ovarian Cancer CircBNC2 Down Associated with histological grade , serous subtype, LNM, and distant metastasis Tissue circRNA;
AUC value: 0.879; Sensitivity: 0.964;
Specificity:0.807		 249 [201]
Bladder cancer Hsa_circ_0001136 Up Correlated with tumor grade, tumor stage, lymph node invasion and distant metastasis Tissue circRNA;
AUC value: 0.770; Sensitivity: 0.686;
Specificity:0.769		 122 [190]
Hsa_circ_0137439 Up Correlated with tumor stage, tumor grade, lymph node status Tissue circRNA;
AUC value: 0.890; Sensitivity: 0.886;
Specificity:0.734		 116 [191]
Papillary thyroid carcinoma Hsa_circ_0137287 Down Correlated with extrathyroidal extension, lymph node metastasis , advanced T stage and tumor size Tissue circRNA;AUC value: 0.8973; Sensitivity: 0.792;
Specificity:0.900		 120 [202]
Pancreatic cancer Circ-IARS Up Correlated with liver metastasis, vascular invasion and TNM stage Exosome circRNA 92 [193]