Table 1.
Factors associated with PD-L1 expression in 78 pathological specimens from 53 MPM patients.
| Characteristic | No. of specimens | PD-L1% | P value |
|---|---|---|---|
| Patient age at diagnosis | 0.28 | ||
| >60 years | 36 | 9.7 (0–88) | |
| ≤60 years | 42 | 14.8 (0–90) | |
| Patient gender | 0.41 | ||
| Male | 51 | 13.9 (0–90) | |
| Female | 27 | 9.8 (0–60) | |
| Histological subtype | 0.93 | ||
| Epithelioid | 73 | 12.3 (0–90) | |
| Biphasic | 5 | 13.2 (0–60) | |
| Nuclear grade score | 0.32 | ||
| 1 | 35 | 14.7 (0–88) | |
| >1 | 38 | 9.9 (0–90) | |
| Nuclear atypia score | 0.63 | ||
| 1 | 11 | 14.4 (0–60) | |
| >1 | 60 | 11.7 (0–90) | |
| Mitotic count score | 0.25 | ||
| 1 | 34 | 15.1 (0–88) | |
| >1 | 38 | 9.6 (0–90) | |
| Necrosis | 0.55 | ||
| Yes | 18 | 12.8 (0–60) | |
| No | 55 | 9.4 (0–90) | |
| BAP1 protein IHC | 0.16 | ||
| Lost | 35 | 10.8 (0–88) | |
| Retained | 15 | 19.3 (0–90) | |
| Germline mutation | 0.04 | ||
| Yes | 13 | 20 (0–60) | |
| No | 53 | 1 (0–90) | |
| Somatic tumour mutation burden | 0.04 | ||
| =1 per Mb | 8 | 0 (0–20) | |
| >1 per Mb | 20 | 7.5 (0–88) | |
| Prior chemotherapy (within 2 years) | 0.02 | ||
| No chemotherapy | 49 | 16 (0–90) | |
| Systemic chemotherapy | 15 | 6 (0–50) | |
| Intraperitoneal chemotherapy | 4 | ||
| Systemic + intraperitoneal | 10 |
Mb mega base pair.
Bold values indicate statistical significance p < 0.05.