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. 2021 Feb 1;6:4. doi: 10.1038/s41536-020-00115-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Salivary gland regeneration phases after radiation-induced damage. Upon radiation damage, a first regeneration phase seems to be characterized by a lineage-restricted response defined by the self-duplication ability of acinar cells (Mist1 and Pip) into acinar cells as well as the replacement of acinar cells driven by immature acinar progenitor-like cells (Sox2) that within the first 30 days post-irradiation are able to maintain the integrity of the acinar cell compartment. The second regeneration phase, marked by an extensive loss of acinar cells, seems to rely on the plasticity properties of the ductal cells (Axin2 and K5) that are able to give rise to new acinar cells. b In the context of tissue damage, salivary gland progenitor cells exhibit plasticity. Depending on the type of injury inflicted, salivary gland cells show different damage-induced plasticity: irradiation-induced plasticity, ligation-induced plasticity, and in vitro induced plasticity (giving rise to an organized 3D system formed by different cell types named organoid) (Figure created with BioRender.com).