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. 2020 Oct 30;124(3):645–657. doi: 10.1038/s41416-020-01135-6

Fig. 5. Acetyl-bufalin inhibited growth of non-small-cell lung cancer (NSCLC) xenograft models.

Fig. 5

a, b Volume and weight of tumour tissue in anatomical nude mice treated with SNS-032(SNS), bufalin (Bu) or acetyl-bufalin (Ac-bu) (2 mg/kg). c Tumour tissue of nude mice treated with SNS-032(SNS), bufalin (Bu) or acetyl-bufalin (Ac-bu) (2 mg/kg). d Nude mouse size growth curve. e Western blot analysis on the expressions of CDK9/STAT3 pathway-associated proteins and apoptosis-related proteins in excised tumour tissue lysates. f Haematoxylin and eosin staining of hearts, livers, lungs and kidneys from the nude mice at ×200 magnification. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.