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. 2020 Oct 30;124(3):645–657. doi: 10.1038/s41416-020-01135-6

Fig. 6. Anti-tumour activity of acetyl-bufalin in a patient-derived (PDX) non-small-cell lung cancer (NSCLC) xenograft animal model.

Fig. 6

a Flowchart for establishing the PDX model. b Tumour volume in the PDX model. c Curve of the tumour weights in the mice. d Images of representative tumours removed from the PDX model. e Body weight curve of the PDX-model nude mice. f Western blot analysis on the expressions of CDK9/STAT3 pathway-associated proteins and apoptosis-related proteins from tumour tissue removed from the PDX mouse model. g Haematoxylin and eosin staining of hearts, livers, lungs and kidneys from the nude mice at ×200 magnification. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.