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. 2021 Feb 1;135(3):465–481. doi: 10.1042/CS20201511

Figure 5. Effects of candesartan and captopril on spike protein internalization in cultures of human alveolar type-II A549 cells.

Figure 5

Effects of candesartan and captopril on SARS-CoV-2 Spike RBD-Fc internalization rate by measuring cytoplasmic fluorescence intensities of spike protein using confocal laser microscopy (A). ACE2-GFP (green), spike protein (red) and merge (yellow) fluorescence in untreated controls (B–D), and cultures treated with spike protein alone (E–G) or spike protein and candesartan (H–J) or spike protein and captopril (K–M). *P<0.05 relative to untreated controls, #P<0.05 relative to cells treated with spike alone (Kruskal–Wallis one–way analysis of variance on ranks with Dunn’s method post hoc test); scale bar (for all photographs): 25 µm.