Fig. 4.

Translating research to practice. Workflow outline of using open software such as QuPath as a training tool for deep learning neural networks within a quality management system which maintains document and software control. Alongside training and competency of laboratory staff, annotators are trained and output is independently reviewed before being used in the training of the network. Change control is thus recorded to aid in the understanding of the development of the neural network for acceptance by regulators and the clinical community.