Figure 1.

Analysis of ccf-mtDNA copy number, fragment size, and breakpoint by low-depth whole genome sequencing (WGS)

(A) Comparison of mtDNA copy number between plasma (orange) and fresh tissues (purple). The significance was determined by a Student’s t test. (B) Fragment size distribution of ccf-mtDNA (orange) and ccf-DNA (purple) among healthy controls, hepatitis patients, HCC patients, and CRC patients. (C) Proportion of ccf-mtDNA breakpoints across the mitochondrial genome among healthy controls, hepatitis patients, HCC patients, and CRC patients. HC, heathy control; HCC, hepatocellular carcinoma; CRC, colorectal cancer.