Figure 5.

Consistency between capture-based approach and low-depth WGS for profiling ccf-mtDNA characteristics

(A) Correlation of mtDNA copy number between optimized capture-based sequencing and low-depth WGS. The significance of correlation was determined by Spearman’s rank correlation coefficient. (B) Distribution of ccf-mtDNA fragment size detected by optimized capture-based sequencing (orange) and low-depth WGS (purple). (C) Distribution of ccf-mtDNA breakpoints across the mitochondrial genome detected by optimized capture-based sequencing (orange) and low-depth WGS (purple).