Figure 2.

Subtype-specific functions of epi-lncRNAs

(A–C) Distribution and function analysis of epi-lncRNAs in the basal (A), luminal (B), and claudin-low (C) subtypes. Distribution and function analysis of epi-lncRNAs in breast cancer subtypes are shown. (D) Distribution of epi-lncRNAs of all three breast cancer subtypes and function analysis of epi-lncRNAs, which are associated with H3K27ac dysregulation. (E) Unsupervised clustering was performed using epigenetically dysregulated lncRNAs at enhancer elements. PAM50 classification, ER, PR, and HER2 status are shown above the heatmap.