FIGURE 2.

Subjects with lower PCSK9 have higher WAT surface LDLR and CD36 expression with upregulated NLRP3 inflammasome activity. Group difference in WAT surface LDLR (a) and CD36 (b), total WAT NLRP3 expression (c), pro‐IL‐1β expression (d), IL‐1β medium accumulation (e), and plasma IL‐1Ra (f). Data presented for N = 13 in the lower and N = 14 in the higher PCSK9 groups except for panel C where N = 11 in the higher PCSK9 group, panel D where N = 12 in the higher PCSK9 group, panel E where N = 12 in the lower and N = 9 in the higher PCSK9 group, and panel F where N = 12 in the higher PCSK9 group due to missing data. Women are presented as closed circles and men as open circles. Significant findings hold when performing non‐parametric sensitivity analysis