Table 2.
The behaviours in the open field for adult mice subjected to repetitive doses of neonatal ketamine exposure
| The open filed | Balb/c | C57BL/6 | |||||
|---|---|---|---|---|---|---|---|
|
|
|
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| Saline (n = 13) | KET10 (n = 11) | KET20 (n = 9) | Saline (n = 10) | KET10 (n = 10) | KET20 (n = 10) | ||
| The time of centre latency | 48.9 ± 12.1 | 37.5 ± 15.7 | 30.4 ± 5.5 | 3.4 ± 0.9*** | 43.5 ± 6.1### | 21.2 ± 6.5## | |
| Frequency of rearing | 20.7 ± 2.0 | 15.7 ± 2.6 | 14.2 ± 3.1 | 45.5 ± 2.8*** | 29.6 ± 2.2### | 20.5 ± 1.6### | |
| Frequency of centre crossing | 25.0 ± 2.9 | 23.9 ± 5.3 | 29.5 ± 3.1 | 37.1 ± 2.5* | 22.4 ± 1.3## | 22.8 ± 2.7## | |
Values are presented as mean ± standard error.
KET10, ketamine 10 mg/kg; KET20, ketamine 20 mg/kg.
*p < 0.05, ***p < 0.001 compared to Balb/c control (saline) group, ## p < 0.01, ### p < 0.001 compared to C57BL/6 control (saline) group.