Table 4.
The behaviours in the elevated plus maze for adult mice subjected to repetitive doses of neonatal ketamine exposure
| The elevated plus maze | Balb/c | C57BL/6 | |||||
|---|---|---|---|---|---|---|---|
|
|
|
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| Saline (n = 13) | KET10 (n = 11) | KET20 (n = 9) | Saline (n = 10) | KET10 (n = 10) | KET20 (n = 10) | ||
| Number entries of in the open arm | 4.6 ± 0.5 | 5.5 ± 0.8 | 4.5 ± 0.4 | 18.3 ± 2.9*** | 7.2 ± 0.8 | 5.9 ± 0.7## | |
| Number of total arm entries | 11.5 ± 0.9 | 12.0 ± 1.2 | 10.4 ± 0.6 | 33.3 ± 3.9*** | 16.9 ± 0.8 | 17.6 ± 1.2## | |
| Enter latency to open arm(s) | 11.6 ± 3.2 | 17.8 ± 5.3 | 16.3 ± 4.9 | 6.6 ± 1.9 | 14.1 ± 2.5 | 38.9 ± 13.0 | |
| The number of head dipping | 3.3 ± 0.8 | 3.7 ± 0.8 | 2.2 ± 0.4 | 10.6 ± 0.9*** | 9.1 ± 1.4 | 4.0 ± 1.1### | |
Values are presented as mean ± standard error of the mean.
KET10, ketamine 10 mg/kg; KET20, ketamine 20 mg/kg.
***p < 0.001 in comparison to the Balb/c control (saline) group, ## p < 0.01, ### p < 0.001 in comparison to the C57BL/6 control (saline) group.