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. 2021 Feb 28;19(1):26–45. doi: 10.9758/cpn.2021.19.1.26

Table 3.

Characteristics of studies evaluating 2D:4D in addictions

Diagnosis First author Year Country Patients Controls Hand 2D:4D measurement tool


Number Mean age (range) Male, n (%) Number Mean age (range) Male, n (%)
Alcohol dependence (DSM-IV) Han 2016 South Korea 87 51.2 (/) 87 (100) 52 48.32 (/) 52 (100) L, R Scanner (indirect)
Alcohol dependence (DSM-5, ICD-10) Lenz 2017 Germany 200 48 (42−54) 113 (56.50) 240 48 (39−56) 133 (55.42) Mean L, R Scanner (indirect)
Alcohol dependence (ICD-10) Kornhuber 2011 Germany 131 / (24−77) 87 (66.41) 185 / (24−77) 83 (44.86) L, R Scanner (indirect)
Heroin dependence (DSM-5) Canan 2018 Turkey 150 22.8 (/) 150 (100) 266 23 (/) 266 (100) L, R Digital Caliper (direct)
Heroin dependence (DSM-IV) Cicek 2017 Turkey 62 24.09 (18−45) 62 (100) 50 24.42 (18−45) 50 (100) R Digital Caliper (direct)

2D:4D, Second-to-fourth Digit Ratio; DSM, Diagnostic and Statistical Manual of Mental Disorders; ICD, International Classification of Diseases; L, left; R, right; /, not available.