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Molecular Mechanism Diagram
MSC-delivered EVs delivered miR-130b-3p into lung cancer cells to inhibit the expression of FOXO3. FOXO3 could promote the expression of Keap1. After inhibiting the expression of FOXO3, the inactivation of Keap1 resulted in the upregulation of NFE2L2, and promoted the expression of TXNRD1, thus promoting cell proliferation and migration but inhibiting cell apoptosis in lung cancer.
