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. 2020 Nov 20;20:23–33. doi: 10.1016/j.omto.2020.11.003

Figure 3.

Figure 3

Administration of HCA-EFZP-IL-12 results in a significant decrease in the percentage of spontaneous lung metastasis

Sarcoma-bearing mice were treated as described in Figure 1 and sacrificed on day 80. (A) Table summarizing the percentages and raw numbers of primary tumor in the bone and spontaneous metastasis found in each group (PBS and HCA-EFZP-IL-12). (B and C) Evaluation of lung metastasis using micro-CT. Quantification of the normal lung parenchyma using micro-CT (B). Representative 3D image reconstruction of the normal lung parenchyma and corresponding histological macroscopic images of tumors in PBS- and HCA-EFZP-IL-12-treated animals (C).