Figure 7.

The novel therapeutic targets were screened out and validated

(A) Top expression genes within exhausted subpopulation 2. Gene symbols were labeled for adjusted p value < 0.05 and log₂ fold change > 1. (B) Kruskal-Wallis curves were plotted to validate the survival values of PMEL, TYRP1, and EDNRB. (C) Gene expression of the novel targets within SKCM and normal RNA-seq samples. The ordinate showed values of log₂(TPM + 1). (D) Average log₂(TPM + 1) values among four pathology stages (∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001). (E) The expression values of TYRP1 across 37 tumors and normal samples (download from FIREBROWSE database).