Figure 1.

Gene mutation patterns in human gallbladder cancer samples

(A) Non-synonymous gene mutations in 10 cancer samples. TP53 is the most frequently mutated gene (60%) followed by ERBB2, OBSCN, and RIN2 (30% for each). (B) Nucleotide mutation pattern for 10 cancer samples. C > T/G > A and C > G/G > C mutation pattern represent the most frequently mutated type. (C) Nucleotide mutation pattern for hyper-mutated G22 sample. C > T/G > A and C > A/G > T mutation patterns represent the most frequently mutated type. (D) Mutation of genes involved in DNA repair in G22 sample.