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Somatic variations of the three ISs
(A−C) Waterfall plots showing the top 10 mutated genes of each IS. (D−F) Circos plots of each IS revealing the gains and losses of chromosomes, with red dots representing gains, blue dots representing losses, and black dots representing no significant CNA. (G−J) Comparisons of the TMB, CNA burden, and number of amplifications and deletions among three ISs. (K) Mutation status of the eight representative molecular biomarkers among the ISs.
