Table 7.
Factors Influencing ORR Achievement by Logistic Regression Model Analysis.
| Parameters | Univariate Logistic Regression | Multivariate Logistic Regression | ||||||
|---|---|---|---|---|---|---|---|---|
| p Value | OR | 95% CI | p Value | OR | 95% CI | |||
| Lower | Higher | Lower | Higher | |||||
| Age >60 years | 0.187 | 0.650 | 0.342 | 1.234 | – | – | – | – |
| Male | 0.765 | 0.875 | 0.365 | 2.100 | – | – | – | – |
| History of HB | 0.066 | 2.026 | 0.955 | 4.299 | 0.150 | 1.727 | 0.821 | 3.633 |
| History of alcohol use | 0.573 | 0.832 | 0.439 | 1.577 | – | – | – | – |
| History of cirrhosis | 0.319 | 1.386 | 0.729 | 2.637 | – | – | – | – |
| Multifocal disease | 0.061 | 0.487 | 0.230 | 1.034 | 0.152 | 0.558 | 0.251 | 1.239 |
| Tumor location: left liver | 0.610 | 0.802 | 0.344 | 1.871 | – | – | – | – |
| Tumor location: right liver | 0.610 | 1.181 | 0.623 | 2.238 | – | – | – | – |
| Tumor location: bilobar | 0.879 | 0.949 | 0.481 | 1.870 | – | – | – | – |
| Largest nodule size >5 cm | 0.722 | 1.123 | 0.592 | 2.130 | – | – | – | – |
| Portal vein invasion | 0.021 | 0.461 | 0.239 | 0.889 | 0.040 | 0.477 | 0.235 | 0.966 |
| Hepatic vein invasion | 0.164 | 0.554 | 0.242 | 1.272 | – | – | – | – |
| Higher ECOG performance status | 0.980 | 1.006 | 0.634 | 1.596 | – | – | – | – |
| Higher Child–Pugh stage | 0.898 | 1.049 | 0.501 | 2.197 | – | – | – | – |
| Higher BCLC stage | 0.544 | 0.881 | 0.584 | 1.328 | – | – | – | – |
| Two or more cycles of DEB-TACE treatment | 0.428 | 1.452 | 0.577 | 3.652 | – | – | – | – |
| Previous cTACE treatment | 0.063 | 0.543 | 0.285 | 1.034 | 0.030 | 0.458 | 0.226 | 0.928 |
| Previous surgery | 0.280 | 0.679 | 0.337 | 1.369 | – | – | – | – |
| Previous systematic chemotherapy | 0.119 | 0.311 | 0.072 | 1.351 | – | – | – | – |
| Previous radiofrequency ablation | 0.311 | 0.641 | 0.271 | 1.516 | – | – | – | – |
| Previous targeted therapy | – | – | – | – | – | – | – | – |
| Combination of ordinary embolization agent | 0.256 | 1.498 | 0.746 | 3.008 | – | – | – | – |
| WBC abnormal | 0.960 | 1.018 | 0.503 | 2.060 | – | – | – | – |
| RBC abnormal | 0.208 | 0.658 | 0.342 | 1.264 | – | – | – | – |
| ANC abnormal | 0.394 | 0.738 | 0.367 | 1.484 | – | – | – | – |
| Hb abnormal | 0.440 | 1.304 | 0.665 | 2.560 | – | – | – | – |
| PLT abnormal | 0.729 | 0.893 | 0.470 | 1.696 | – | – | – | – |
| ALB abnormal | 0.935 | 1.028 | 0.532 | 1.987 | – | – | – | – |
| TP abnormal | 0.806 | 1.097 | 0.523 | 2.302 | – | – | – | – |
| TBIL abnormal | 0.468 | 1.314 | 0.629 | 2.744 | – | – | – | – |
| TBA abnormal | 0.860 | 0.940 | 0.473 | 1.869 | – | – | – | – |
| ALT abnormal | 0.149 | 1.957 | 0.786 | 4.876 | – | – | – | – |
| AST abnormal | 0.575 | 1.207 | 0.625 | 2.330 | – | – | – | – |
| ALP abnormal | 0.388 | 0.749 | 0.389 | 1.443 | – | – | – | – |
| BCr abnormal | 0.010 | 0.347 | 0.155 | 0.776 | 0.017 | 0.353 | 0.149 | 0.833 |
| BUN abnormal | 0.342 | 0.644 | 0.259 | 1.596 | – | – | – | – |
| AFP abnormal | 0.736 | 1.119 | 0.581 | 2.154 | – | – | – | – |
| CEA abnormal | 0.621 | 1.267 | 0.497 | 3.231 | – | – | – | – |
| CA199 abnormal | 0.639 | 0.837 | 0.399 | 1.758 | – | – | – | – |
Data was presented as p value, OR, and 95% CI. Factors affecting ORR achievement were determined by univariate logistic regression analysis, while all factors with a value of p ≤ 0.1 were further detected by multivariate logistic regression analysis. A value of p < 0.05 was considered significant. Child–Pugh stage was scored as 0—A, 1—B, 2—C; BCLC stage was scored as 0—Stage 0, 1—Stage A, 2—Stage B, 3—Stage C, 4—Stage D. The logistic analysis was performed based on these definitions.