Table 8.
Cox’s Proportional Hazards Regression Model Analysis of Factors Predicting Progression-Free Survival (PFS)
| Parameters | Univariate Cox’s Regression | Multivariate Cox’s Regression | ||||||
|---|---|---|---|---|---|---|---|---|
| p Value | HR | 95% CI | p Value | HR | 95% CI | |||
| Lower | Higher | Lower | Higher | |||||
| Age >60 years | 0.119 | 0.515 | 0.224 | 1.185 | – | – | – | – |
| Male | 0.770 | 0.865 | 0.326 | 2.293 | – | – | – | – |
| HBV positive | 0.759 | 0.858 | 0.324 | 2.276 | – | – | – | – |
| Drink | 0.746 | 1.136 | 0.526 | 2.450 | – | – | – | – |
| Cirrhosis | 0.376 | 0.706 | 0.327 | 1.525 | – | – | – | – |
| Multifocal disease | 0.112 | 2.204 | 0.831 | 5.848 | – | – | – | – |
| Tumor location: left liver | 0.616 | 0.735 | 0.221 | 2.448 | – | – | – | – |
| Tumor location: right liver | 0.544 | 0.787 | 0.364 | 1.703 | – | – | – | – |
| Tumor location: bilobar | 0.306 | 1.502 | 0.690 | 3.273 | – | – | – | – |
| Largest nodule size ≥5 cm | 0.052 | 2.281 | 0.991 | 5.249 | 0.801 | 1.152 | 0.384 | 3.455 |
| Portal vein invasion | 0.002 | 3.486 | 1.601 | 7.592 | 0.857 | 1.108 | 0.363 | 3.385 |
| Hepatic vein invasion | 0.696 | 1.237 | 0.426 | 3.589 | – | – | – | – |
| Higher ECOG performance status | 0.419 | 1.221 | 0.752 | 1.982 | – | – | – | – |
| Higher Child–Pugh stage | 0.434 | 1.354 | 0.634 | 2.893 | – | – | – | – |
| Higher BCLC stage | 0.003 | 2.467 | 1.362 | 4.469 | 0.029 | 2.613 | 1.101 | 6.202 |
| Two or more cycles of DEB-TACE treatment | 0.125 | 0.322 | 0.076 | 1.368 | – | – | – | – |
| Previous cTACE treatment | 0.751 | 1.133 | 0.524 | 2.450 | – | – | – | – |
| Previous surgery | 0.246 | 1.613 | 0.719 | 3.621 | – | – | – | – |
| Previous systematic chemotherapy | 0.822 | 1.258 | 0.170 | 9.293 | – | – | – | – |
| Previous radiofrequency ablation | 0.706 | 1.227 | 0.423 | 3.562 | – | – | – | – |
| Previous targeted therapy | 0.545 | 0.047 | 0.000 | 909.298 | – | – | – | – |
| Combination of ordinary embolization agent | 0.595 | 1.235 | 0.567 | 2.690 | – | – | – | – |
| WBC abnormal | 0.061 | 2.092 | 0.968 | 4.524 | 0.235 | 1.791 | 0.685 | 4.683 |
| RBC abnormal | 0.055 | 2.156 | 0.984 | 4.726 | 0.517 | 1.384 | 0.518 | 3.694 |
| ANC abnormal | 0.098 | 1.966 | 0.883 | 4.377 | 0.385 | 1.539 | 0.582 | 4.071 |
| HB abnormal | 0.352 | 1.452 | 0.662 | 3.182 | – | – | – | – |
| PLT abnormal | 0.491 | 1.311 | 0.607 | 2.830 | – | – | – | – |
| ALB abnormal | 0.174 | 1.706 | 0.790 | 3.682 | – | – | – | – |
| TP abnormal | 0.494 | 0.711 | 0.268 | 1.887 | – | – | – | – |
| TBIL abnormal | 0.129 | 1.828 | 0.840 | 3.981 | – | – | – | – |
| TBA abnormal | 0.116 | 1.917 | 0.852 | 4.316 | – | – | – | – |
| ALT abnormal | 0.193 | 1.740 | 0.756 | 4.006 | – | – | – | – |
| AST abnormal | 0.113 | 1.878 | 0.862 | 4.091 | – | – | – | – |
| ALP abnormal | 0.001 | 4.003 | 1.740 | 9.208 | 0.053 | 2.550 | 0.989 | 6.574 |
| BCr abnormal | 0.002 | 3.772 | 1.636 | 8.695 | 0.240 | 1.900 | 0.652 | 5.539 |
| BUN abnormal | 0.081 | 2.252 | 0.904 | 5.610 | 0.285 | 1.812 | 0.609 | 5.388 |
| AFP abnormal | 0.196 | 1.834 | 0.732 | 4.597 | – | – | – | – |
| CEA abnormal | 0.252 | 1.731 | 0.677 | 4.425 | – | – | – | – |
| CA199 abnormal | 0.007 | 3.069 | 1.354 | 6.956 | 0.255 | 1.783 | 0.659 | 4.822 |
Data are presented as p value, HR (hazards ratio), and 95% CI. Factors affecting PFS were determined by univariate Cox’s proportional hazards regression model analysis, while all factors with a value of p ≤ 0.1 were further detected by multivariate Cox’s proportional hazards regression analysis. A value of p < 0.05 was considered significant. Child–Pugh stage was scored as 0—A, 1—B, 2—C; BCLC stage was scored as 0—stage 0, 1—stage A, 2—stage B, 3—stage C, 4—stage D. The logistic analysis was performed based on these definitions.