Table 9.
Cox’s Proportional Hazards Regression Model Analysis of Factors Predicting Overall Survival (OS)
| Parameters | Univariate Cox’s Regression | Multivariate Cox’s Regression | ||||||
|---|---|---|---|---|---|---|---|---|
| p Value | HR | 95% CI | p Value | HR | 95% CI | |||
| Lower | Higher | Lower | Higher | |||||
| Age >60 years | 0.066 | 0.243 | 0.054 | 1.098 | 0.248 | 0.332 | 0.051 | 2.158 |
| Male | 0.833 | 1.176 | 0.261 | 5.307 | – | – | – | – |
| History of HB | 0.576 | 0.692 | 0.190 | 2.515 | – | – | – | – |
| History of alcohol use | 0.953 | 0.967 | 0.325 | 2.879 | – | – | – | – |
| History of cirrhosis | 0.179 | 0.464 | 0.152 | 1.423 | – | – | – | – |
| Multifocal disease | 0.429 | 1.684 | 0.463 | 6.125 | – | – | – | – |
| Tumor location: left liver | 0.330 | 0.039 | 0.000 | 27.060 | – | – | – | – |
| Tumor location: right liver | 0.689 | 0.800 | 0.269 | 2.383 | – | – | – | – |
| Tumor location: bilobar | 0.120 | 2.376 | 0.798 | 7.076 | – | – | – | – |
| Largest nodule size >5 cm | 0.031 | 5.242 | 1.161 | 23.675 | 0.445 | 2.319 | 0.268 | 20.07 |
| Portal vein invasion | 0.019 | 3.810 | 1.246 | 11.652 | 0.363 | 2.713 | 0.316 | 23.322 |
| Hepatic vein invasion | 0.807 | 1.207 | 0.267 | 5.448 | – | – | – | – |
| Higher ECOG performance status | 0.048 | 1.765 | 1.004 | 3.102 | 0.550 | 0.719 | 0.244 | 2.122 |
| Higher Child–Pugh stage | 0.045 | 2.242 | 1.017 | 4.945 | 0.374 | 2.065 | 0.418 | 10.203 |
| Higher BCLC stage | 0.064 | 2.169 | 0.956 | 4.922 | 0.090 | 3.387 | 0.827 | 13.873 |
| Two or more cycles of DEB-TACE treatment | 0.246 | 0.298 | 0.038 | 2.305 | – | – | – | – |
| Previous cTACE treatment | 0.377 | 0.588 | 0.181 | 1.910 | – | – | – | – |
| Previous surgery | 0.423 | 0.540 | 0.120 | 2.439 | – | – | – | – |
| Previous systematic chemotherapy | 0.350 | 2.645 | 0.343 | 20.369 | – | – | – | – |
| Previous radiofrequency ablation | 0.753 | 1.273 | 0.282 | 5.746 | – | – | – | – |
| Previous targeted therapy | 0.670 | 0.047 | 0.000 | 58203 | – | – | – | – |
| Combination of ordinary embolization agent | 0.551 | 1.394 | 0.468 | 4.151 | – | – | – | – |
| WBC abnormal | 0.206 | 2.022 | 0.679 | 6.018 | – | – | – | – |
| RBC abnormal | 0.025 | 3.958 | 1.192 | 13.149 | 0.684 | 1.44 | 0.249 | 8.325 |
| ANC abnormal | 0.593 | 1.387 | 0.418 | 4.608 | – | – | – | – |
| Hb abnormal | 0.445 | 1.555 | 0.501 | 4.824 | – | – | – | – |
| PLT abnormal | 0.804 | 1.148 | 0.385 | 3.423 | – | – | – | – |
| ALB abnormal | 0.003 | 9.934 | 2.199 | 44.864 | 0.011 | 34.757 | 2.232 | 541.132 |
| TP abnormal | 0.900 | 0.921 | 0.253 | 3.349 | – | – | – | – |
| TBIL abnormal | 0.004 | 5.745 | 1.768 | 18.663 | 0.009 | 13.287 | 1.897 | 93.056 |
| TBA abnormal | 0.435 | 1.544 | 0.519 | 4.594 | – | – | – | – |
| ALT abnormal | 0.369 | 1.716 | 0.528 | 5.582 | – | – | – | – |
| AST abnormal | 0.025 | 4.400 | 1.210 | 16.005 | 0.798 | 0.776 | 0.111 | 5.435 |
| ALP abnormal | 0.028 | 3.757 | 1.157 | 12.202 | 0.570 | 0.593 | 0.098 | 3.599 |
| BCr abnormal | 0.004 | 5.219 | 1.705 | 15.982 | 0.107 | 3.614 | 0.758 | 17.231 |
| BUN abnormal | 0.057 | 3.144 | 0.968 | 10.214 | 0.887 | 0.88 | 0.15 | 5.158 |
| AFP abnormal | 0.192 | 2.750 | 0.602 | 12.570 | – | – | – | – |
| CEA abnormal | 0.408 | 1.751 | 0.464 | 6.605 | – | – | – | – |
| CA199 abnormal | 0.052 | 3.247 | 0.991 | 10.642 | 0.669 | 1.465 | 0.254 | 8.442 |
Data are presented as p value, HR, and 95% CI. Factors affecting OS were determined by univariate Cox’s proportional hazards regression model analysis, while all factors with a value of p ≤ 0.1 were further detected by multivariate Cox’s proportional hazards regression analysis. A value of p < 0.05 was considered significant. Child–Pugh Stage was scored as 0—A, 1—B, 2—C; BCLC stage was scored as 0—stage 0, 1—stage A, 2—stage B, 3—stage C, 4—stage D. The logistic analysis was performed based on these definitions.