Table 1.

Binding Affinities of APG-2575 and Reference Compounds to BCL-2, BCL-XL, and MCL-1

Target	Drugs	BCL-2 (nM) K i	BCL-XL (nM) K i	BCL-W (nM) K i	MCL-1 (nM) K i
BCL-2/BCL-XL	ABT-263*	1	<0.5	1	No binding affinity
BCL-2	ABT-199*	<0.1	<0.5	No	No binding affinity
BCL-2	APG-2575	<0.1	<0.5	No	No binding affinity

^*Data from Selleck (https://www.selleck.cn/).