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Schematic representation of the RPSAP52 mechanisms. In the absence of RPSAP52, miRNAs bind the 3′-UTR of the HMGA1 and HMGA2 gene, reducing the synthesis of the relative proteins. RPSAP52, overexpressed, is able to bind miRNAs and recruit HuR, readdressing miRNAs from the high mobility group A (HMGA) to CDKN1A, with reduction of p21Waf1/CIP protein levels and release of HMGA proteins.
