Table 3.
Association of Differentially Expressed DNA Damage Genes and Cell Cycle Genes With Outcome After Radiotherapy
| Gene Name | TCGA: RT− | TCGA: RT+ |
|---|---|---|
| DNA damage repair | ||
| Increased | ||
| EME2 | 0.03 | 0.37 |
| NEIL1 | 0.44 | 0.10 |
| Decreased | ||
| PCNA * | 0.56 | 0.38 |
| BRIP1 | 0.19 | 0.30 |
| BARD1 | 0.78 | 0.32 |
| Cell cycle | ||
| Increased | ||
| MAPK12 | 0.31 | 0.16 |
| Decreased | ||
| E2F2 | 0.74 | 0.47 |
| CKS2 | 0.62 | 0.77 |
| GINS2 | 0.40 | 0.26 |
| PCNA * | 0.56 | 0.38 |
| MCM5 | 0.67 | 0.33 |
| EIF5A2 | 0.37 | 0.89 |
| CCND1 | 0.28 | 0.68 |
| MYC | 0.15 | 0.08 |
For each of the DNA damage genes and cell cycle genes that were differentially expressed in MCF-7TAM, the p values of the association with relapse-free survival in patients treated with or without radiotherapy in the TCGA breast cancer cohort are depicted, based on the Breslow test.
*
PCNA is both a DNA damage repair and a cell cycle gene.