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. 2020 May 29;28(3):249–271. doi: 10.3727/096504019X15766663541105

Table 4.

Factors Affecting CR Achievement by Logistic Regression Model Analysis

Parameters Univariate Logistic Regression Multivariate Logistic Regression
p Value OR 95% CI p Value OR 95% CI
Lower Higher Lower Higher
Age ≥65 years 0.094 0.607 0.339 1.088 0.221 0.643 0.316 1.305
Male 0.506 1.244 0.654 2.367
History of HB 0.002 2.759 1.448 5.256 0.148 2.004 0.781 5.144
History of HC 0.995 1.007 0.111 9.146
History of drink 0.496 1.196 0.714 2.005
History of cirrhosis 0.795 1.070 0.641 1.787
Primary HCC 0.015 2.437 1.193 4.977 0.325 1.958 0.513 7.465
Primary ICC 0.071 0.328 0.098 1.099
Secondary liver cancer 0.154 0.544 0.235 1.257
Multifocal disease 0.009 0.498 0.295 0.840 0.151 0.595 0.293 1.208
Tumor location: left liver 0.163 1.596 0.828 3.077
Tumor location: right liver 0.230 1.371 0.819 2.297
Tumor location: bilobar 0.022 0.500 0.277 0.904 0.316 0.686 0.328 1.434
Largest nodule size ≥5 cm 0.003 0.442 0.259 0.755 0.111 0.574 0.291 1.135
Portal vein invasion 0.001 0.258 0.119 0.559 0.010 0.253 0.088 0.722
Hepatic vein invasion 0.086 0.429 0.164 1.126 0.934 0.948 0.271 3.315
Higher ECOG performance status 0.010 0.581 0.385 0.877 0.489 0.836 0.503 1.390
Higher Child–Pugh Stage 0.244 0.637 0.298 1.360
Higher BCLC Stage 0.008 0.625 0.441 0.885 0.774 1.068 0.683 1.668
Two or more cycles of DEB-TACE treatment 0.908 0.960 0.482 1.913
Previous cTACE treatment 0.491 1.202 0.712 2.027
Previous surgery 0.845 0.945 0.537 1.663
Previous systematic chemotherapy 0.398 0.693 0.297 1.621
Previous radiofrequency ablation 0.098 0.471 0.193 1.148 0.121 0.462 0.174 1.227
Previous targeted therapy 0.776 0.800 0.171 3.733
Higher DEBs size 0.286 0.326 0.042 2.551
Higher drug dosage 0.424 1.488 0.555 3.988
Combination of ordinary embolization agent 0.253 0.715 0.401 1.272
WBC abnormal 0.965 0.987 0.550 1.770
RBC abnormal 0.332 0.765 0.445 1.315
ANC abnormal 0.072 0.559 0.296 1.054 0.379 0.722 0.349 1.492
Hb abnormal 0.187 0.699 0.411 1.190
PLT abnormal 0.593 1.152 0.685 1.939
ALB abnormal 0.024 0.522 0.297 0.917 0.466 0.773 0.387 1.545
TP abnormal 0.331 1.324 0.752 2.333
TBIL abnormal 0.339 1.318 0.748 2.322
TBA abnormal 0.753 1.091 0.635 1.874
ALT abnormal 0.762 0.907 0.483 1.705
AST abnormal 0.031 0.541 0.310 0.944 0.725 0.884 0.445 1.755
ALP abnormal 0.142 0.660 0.380 1.148
BCr abnormal 0.951 0.976 0.449 2.121
BUN abnormal 0.146 0.545 0.241 1.234
AFP abnormal 0.267 0.746 0.445 1.252
CEA abnormal 0.178 0.643 0.338 1.223
CA199 abnormal 0.558 0.841 0.471 1.501

Data are presented as p value, OR (odds ratio), and 95% CI (confidence interval). Factors affecting CR achievement were determined by univariate logistic regression analysis, while all factors with p value no more than 0.1 were further detected by multivariate logistic regression analysis. A value of p < 0.05 was considered significant (bold). Child–Pugh stage was scored as 0—A, 1—B, 2—C; BCLC stage was scored as 0—stage 0, 1—stage A, 2—stage B, 3—stage C, 4—stage D. The logistic analysis was performed based on these definitions.